Enclomiphene

Category Sexual Health & Fertility

Description Enclomiphene is a selective estrogen receptor modulator (SERM) that acts as the trans-isomer of clomiphene citrate. It functions by blocking estrogen receptors in the hypothalamus and pituitary gland, leading to increased secretion of gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), and follicle-stimulating hormone (FSH). This cascade effect stimulates natural testosterone production in men while maintaining fertility, making it distinct from traditional testosterone replacement therapy. Enclomiphene has been studied for treating secondary hypogonadism and improving testosterone levels without suppressing spermatogenesis. Its selective mechanism makes it valuable for research into male reproductive health and hormonal regulation.